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The right choice depends on what you value most: maximum efficacy with managed side effects, or minimal disruption with limited outcomes

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Targeting gamma-glutamyl transpeptidase: a pleiotropic enzyme involved in glutathione metabolism and in the control of redox homeostasis

In SURMOUNT-1 (NEJM 2022, 2,539 adults with obesity), the 15 mg arm averaged 22.5% body weight loss at 72 weeks, the 10 mg arm 21.4%, and the 5 mg arm 16.0%

It triggers fat release and reduces the growth of new fat from cells

Se puede producir una hipocalemia fatal cuando la anemia megaloblstica grave se trata intensivamente con vitamina B12, como resultado del aumento de los requerimientos de eritrocitos y potasio